Job Details

Job Title: Director, Statistical Innovation and Modeling

Location: San Diego, CA / Hybrid / Remote

Position type: Full time

FLSA: Exempt

Department: Biometrics

Finance ID: 7585-2024-1-N

Strive to Bring a Profound Difference to our Patients

At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people's lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients.

Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is broadening the reach of AOCs with its advancing and expanding pipeline, including programs in cardiology and immunology through internal discovery efforts and key partnerships. Avidity is headquartered in San Diego, CA.

The Opportunity

Avidity's commitment to addressing rare diseases demands the use of advanced statistical methods and innovative approaches to overcome challenges and improve data-driven insights in both clinical and real-world settings. Within the Biometrics department, the Statistical Modeling and Innovation function plays a crucial role in enhancing analytical capabilities to support drug development and regulatory decision-making. This leadership position focuses on optimizing statistical methods for data-driven decision-making, utilizing clinical study data along with other internal and external data sources.

What You Will Contribute

• Advanced Statistical Modeling & Simulation: Develop and apply sophisticated statistical models to optimize study design, analyze complex datasets, and enhance predictive capabilities.
• Real-World Evidence (RWE) Analysis: Integrate and analyze real-world data (RWD) to generate actionable insights that complement clinical trial findings.
• Comparative Data Analysis: Assess and compare natural history data with clinical trial outcomes to contextualize treatment effects and disease progression.
• Innovative Analytical Methods: Explore and implement novel statistical techniques, including AI-driven analytics and Bayesian methods, to extract meaningful patterns from diverse data sources.
• Ad Hoc & Exploratory Analyses: Conduct flexible, rapid-response analyses to address emerging scientific and regulatory questions.
• Cross-Functional Collaboration: Work closely with Biostatistics, Statistical Programming, and other R&D teams to enhance study design, data interpretation, and evidence generation strategies.

What We Seek

• Ph.D in Statistics or equivalent with a minimum of 12 years of direct experience in drug development.
• A minimum of 8 years of Management and/or Leadership experience.
• Experience in modeling, simulation, real world evidence and ad hoc analyses in cross-functional working environment.
• Capable of making independent decisions in methodology selection and analysis implementation.
• Experience of using common statistics software such as R and SAS.
• Experience using cutting-edge statistical methodologies to enhance data-driven insights across clinical and real-world settings.
• Experience with innovation in statistical methodologies and data science to strengthen data-informed decision-making, enhance regulatory submissions, and accelerate the development of breakthrough therapies.

What We Will Provide To You

• The base salary range for this role is $232,750-257,250. The final compensation will be commensurate with such factors as relevant experience, skillset, internal equity and market factors.
• Avidity offers competitive compensation and benefits, which include the opportunity for annual and spot bonuses, stock options, and RSUs, as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, and LTD, and four weeks of time off.
• A commitment to learning and development which includes a variety of programming internally developed by and for Avidity employees, opportunities for job-specific training offered by industry, and an education reimbursement program.

Avidity Biosciences

10578 Science Center Dr. Suite 125

San Diego, CA 92121

O: 858-###-####

F: 858-###-####